TOPICS: Exogenous estrogens, binds estrogen receptors, ethinyl estradiol, diethylstilbestrol, des, clear cell adenocarcinoma of vagina, mestranol, hypogonadism, ovarian failure, menstrual abnormalities, menopause, weight gain, slowed metabolism, hot flashes, vaginal atrophy, hormone replacement therapy in postmenopausal women, increases estrogen, decrease osteoclast activity, osteoporosis, increased cardiovascular risk, risk of endometrial cancer, unopposed estrogen without progesterone leads to endometrial carcinoma, bleeding, risk of thrombi, contraindicated in woman>35 years old who use tobacco, er+ breast cancer, history of dvt