TOPICS: Goserelin, leuprolide, gnrh analogs, pulsatile fashion they acts as gnrh agonists, continuous use they act as gnrh antagonists, decreased lh and fsh, low testosterone, leydig cells, decreased estrogen synthesis, granulosa cells, uterine fibroids, endometriosis, precocious puberty, prostatic carcinoma, infertility, hypogonadism, decrease libido, erectile dysfunction, nausea, vomiting, degarelix, gnrh antagonist, hot flashes, liver toxicity