TOPICS: Loop diuretics, thick ascending limb of Loop of Henle, furosemide, torsemide, bumetanide, sulfonamide, block NKCC on ascending limb of Loop of Henle, sodium/potassium/chloride excretion, osmotic power, afferent arteriole, efferent arteriole, prostaglandin release, nephrotic syndrome, hypertension, heart failure, pulmonary edema, edema, ascites, liver cirrhosis, dehydration, gout, hyperuricemia, ototoxicity, hypokalemia, metabolic acidosis, calcium and magnesium excretion, acute interstitial nephritis, ethacrynic acid, not a sulfonamide, sulfonamide related hypersensitivity