Pharmacology

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Pharmacology Fundamentals (8 Videos / Run Time: 1:53:50)
Section I - Enzyme Kinetics (16:04)
TOPICS: Enzyme kinetics, michaelis-menten plots, reaction velocity, rate of reaction, vmax, enzyme concentration, substrate concentration, km, enzyme affinity, lineweaver-burk plot, competitive inhibitors, noncompetitive inhibitors, binding site, active site, allosteric site
Section II - Pharmacokinetics and Dosage Calculations (12:44)
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Section III - Drug Metabolism, Elimination, and Urine pH (11:01)
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Section IV - Efficacy, Potency, Activity at Cell Receptors, and Therapeutic Index (15:24)
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Section V - Drug-drug Interactions (7:45)
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Cytochrome P450 Section VI - Cytochrome P-450 (21:55)
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Beers CriteriaSection VII - Beers Criteria (11:35)
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seafood toxin imageSection VIII - Seafood Toxins (17:22)
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Autonomic Pharmacology (14 Videos / Run Time: 4:12:18)
Adrenergic Receptors Section I - Adrenergic Receptors (26:05)
TOPICS: Alpha-1 receptors, gpcr, gq protein, phospholipase c activation, pip2, ip3, dag, pkc, calcium, pupillary dilator muscle contraction, mydriasis (dilated pupils), alpha-1 stimulation, vascular smooth muscle contraction, vasoconstriction, internal urethral sphincter muscle contraction, alpha-2 receptors, gq protein, adenylate cyclase, camp, norepinephrine (ne) release, aqueous humor production, intraocular pressure, insulin release, lipolysis, platelet aggregation, beta1, beta2, beta3, gs protein, contractility, inotropy, inotropic, chronotropy,chronotropic, renin, lipolysis, vasodilation, skeletal muscle, coronary arteries, bronchodilation/bronchial relaxation, potassium, glycogenolysis, uterine tone, detrusor smooth muscle, bladder capacity, thermogenesis
Epinephrine and Norepinephrine Section II - Epinephrine and Norepinephrine (25:19)
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Alpha Agonists Section III - Alpha Agonists (18:16)
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Beta Agonists Section IV - Beta Agonists (16:47)
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Alpha Blockers Section V - Alpha Blockers (20:21)
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Beta Blockers Section VI - Beta Blockers (19:03)
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Nicotinic Acetylcholine ReceptorsSection VII - Nicotinic Acetylcholine Receptors (7:35)
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Muscarinic Acetylcholine ReceptorsSection VIII - Muscarinic Acetylcholine Receptors (15:28)
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Direct Cholinergic AgonistsSection IX - Direct Cholinergic Agonists (19:59)
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Indirect Cholinergic AgonistsSection X - Indirect Cholinergic Agonists (20:44)
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Anticholinesterase PoisoningSection XI - Anticholinesterase Poisoning (16:14)
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Muscarinic AntagonistsSection XII - Muscarinic Antagonists (12:53)
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AtropineSection XIII - Atropine (14:02)
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Dopamine, Histamine, and Vasopressin ReceptorsSection XIV - Dopamine, Histamine, and Vasopressin Receptors(19:32)
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Immunology Pharmacology (9 Videos / Run Time: 1:11:29)
cyclosporineSection I - Cyclosporine (7:36)
TOPICS: Cyclosporine, cyclophilin, calcineurin, immunomodulator, blocks t-cell, blocks IL-2 gene, block transcription, rheumatoid arthritis, treatment, psoriasis, acute transplant rejection, gingival hyperplasia, hypertension, gout, risk of infection, risk of malignancy, hyperlipidemia, neurotoxicity, tremor, nephrotoxicity, renal tubular acidosis, RTA
tacrolimusSection II - Tacrolimus (4:57)
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sirolimusSection III - Sirolimus (7:47)
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basiliximabSection IV - Basiliximab (4:03)
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azathioprineSection V - Azathioprine and 6 MP (11:26)
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mycophenolateSection VI - Mycophenolate (5:27)
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glucocorticoidsSection VII - Glucocorticoids (14:56)
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bone marrow stimulationSection VIII - Bone Marrow Stimulation (6:38)
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interferonsSection IX - Interferons Alpha, Beta and Gamma (8:39)
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Antibiotics (24 Videos / Run Time: 3:22:13)
penicillinSection I - Penicillin G,V (9:43)
TOPICS: Penicillin, beta lactam rings, pbp, penicillin binding proteins, cell wall cross linking, peptidoglycan, resistance, beta lactamases, syphilis, actinomyces, neisseria meningitidis, strep agalactiae, intrapartum period, rheumatic fever, strep pyogenes, m protein, strep pharyngitis, strep pneumoniae, hypersensitivity, autoimmune hemolytic anemia, allergic reactions, acute interstitial nephritis, serum sickness, stevens johnson syndrome
aminopenicillinsSection II - Amoxicillin and Ampicillin (11:17)
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antistaphSection III - Antistaphylococcal Penicillins (5:19)
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antipseudomonalSection IV - Antipseudomonal Penicillins (8:02)
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cephalosporinsSection V - Cephalosporins (18:18)
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carbapenemsSection VI - Carbapenems (6:42)
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monobactamsSection VII - Monobactams (6:16)
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vancomycinSection VIII - Vancomycin (10:38)
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bacitracinSection IX - Bacitracin (2:33)
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aminoglycosidesSection X - Aminoglycosides (9:55)
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tetracyclinesSection XI - Tetracyclines (9:41)
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glycylocyclinesSection XII - Glycylcyclines (5:37)
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chloramphenicolSection XIII - Chloramphenicol (9:08)
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clindamycinSection XIV - Clindamycin (7:37)
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linezolidSection XV - Linezolid (4:42)
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macrolidesSection XVI - Macrolides (11:44)
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polymyxinsSection XVII - Polymyxins (4:57)
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TrimethoprimSection XVIII - Trimethoprim and Sulfonamides (12:34)
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fluoroquinolonesSection XIX - Fluoroquinolones (8:14)
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daptomycinSection XX - Daptomycin (5:46)
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metronidazoleSection XXI - Metronidazole (5:59)
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dapsoneSection XXII - Dapsone, Rifamycins, Clofazimine (Leprosy Drugs) (11:27)
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isoniazidSection XXIII - Isoniazid (RIPE) (9:18)
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ethambutolSection XXIV - Ethambutol and Pyrazinamide (6:46)
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Antifungals (5 Videos / Run Time: 0:37:51)
amphotericin BSection I - Amphotericin B, Nystatin, and Flucytosine (13:09)
TOPICS: Amphotericin b, ergosterol, electrolyte leakage, cryptococcus, flucytosine, 5 fluorouracil, bone marrow suppression, intrathecal, meningitis, coccidioidomycosis, blastomycosis, histoplasmosis, candida, mucor, human cholesterol, fever, chills, kidney damage, hydrated, magnesium, potassium, arrhythmia, anemia, hypotension, liposomal, thrombophlebitis, nystatin, candida, topical, esophageal and oral candidiasis
azolesSection II - Azoles (11:23)
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terbinafineSection III - Terbinafine (3:47)
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echinocandinsSection IV - Echinocandins (3:44)
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griseofulvinSection V - Griseofulvin (5:48)
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Antiparasitic Drugs (1 Video / Run Time: 0:05:46)
malathionSection I - Malathion, Permethrin, and Lindane (5:46)
TOPICS: Neuronal synapse, acetylcholinesterase, malathion, neurotoxicity, conjunctivitis, permethrin, sodium channel, lindane, gaba, ataxia, burning sensation, pediculus infections, lice, scabies
Antivirals (10 Videos / Run Time: 1:03:34)
oseltamivirSection I - Oseltamivir and Zanamivir (2:31)
TOPICS: Oseltamivir, Zanamivir, antiviral, Tamiflu, inhibit neuraminidase, decreased release of viral progeny, influenza A, influenza B, within 48 hours, decrease illness duration
valacyclovirSection II - Acyclovir, Valacyclovir, and Famciclovir (7:53)
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ganciclovirSection III - Ganciclovir and Valganciclovir (6:08)
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foscarnetSection IV - Foscarnet and Cidofovir (7:18)
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NRTIsSection V - NRTIs (9:22)
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NNRTIsSection VI - NNRTIs (5:53)
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proteaseSection VII - Protease Inhibitors (7:34)
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IntegraseSection VIII - Integrase Inhibitors (4:43)
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fusionSection IX - Fusion Inhibitors (6:28)
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HepCtherapySection X - Hepatitis C Therapy (5:44)
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Cardiac Pharmacology (22 Videos / Run Time: 4:02:18)
hypertension treatmentSection I - Hypertension Treatment (17:39)
TOPICS: Primary hypertension, essential hypertension, thiazide, ace inhibitors, angiotensin receptor blockers, calcium channel blockers, asthma, cough, bronchoconstriction, cardioselective beta blockers, diabetes mellitus, D diabetic nephropathy, hypoglycemia, pregnancy, hydralazine, labetalol, methyldopa, nifedipine, heart failure, loop diuretics, sacubitril, cardiogenic shock, decompensated heart failure, aldosterone antagonists
calcium channelSection II - Calcium Channel Blockers (13:37)
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hydralazineSection III - Hydralazine (8:19)
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fenoldopamSection IV - Fenoldopam and Nitroprusside (9:50)
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nitratesSection V - Nitrates (13:13)
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ranolazineSection VI - Ranolazine (4:32)
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milrinoneSection VII - Milrinone (6:19)
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sacubitrilSection VIII - Sacubitril (8:49)
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statinsSection IX - Statins (8:36)
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bile acid resinsSection X - Bile Acid Resins (6:56)
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ezetimibeSection XI - Ezetimibe (3:50)
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fibratesSection XII - Fibrates (9:02)
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niacinSection XIII - Niacin (7:57)
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PCSK9Section XIV - PCSK9 Inhibitors (6:22)
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fish oilSection XV - Fish Oil, and Omega-3 Fatty Acids (3:57)
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digoxinSection XVI - Digoxin (12:52)
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IA IB IC antiarrhythmicsSection XVII - Class IA, IB, and IC Antiarrhythmics (23:51)
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II antiarrhythmicsSection XVIII - Class II Antiarrhythmics (23:08)
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III antiarrhymthmicsSection XIX - Class III Antiarrhythmics (16:28)
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IV antiarrhythmicsSection XX - Class IV Antiarrhythmics (14:18)
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antiarrhythmicsSection XXI - Other Antiarrhythmics (Adenosine and Magnesium) (15:25)
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ivabradineSection XXII - Ivabradine (7:18)
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Endocrine Pharmacology (14 Videos / Run Time: 1:30:23)
insuin prepSection I - Insulin Preparations (8:16)
TOPICS: Regular insulin, 2-3 hour peak, diabetic ketoacidosis, hyperkalemia, stress hyperglycemia, rapid acting preparations, 1 hour peak, lispro, aspart, glulisine, nph, intermediary acting, 4-10 hour peak, long acting preparations, detemir, glargine, insulin receptor, tyrosine kinase receptor, glycogen, protein synthesis, triglyceride storage, potassium, hypoglycemia, lipodystrophy, weight gain, hypersensitivity
biguanidesSection II - Biguanides (Metformin) (7:05)
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glitazonesSection III - Glitazones/Thiazolidinediones (7:13)
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sulfonylureasSection IV - Sulfonylureas and Meglitinides (7:36)
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amylinSection V - Amylin analogs and GLP-1 analogs (7:17)
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DPP-4Section VI - DPP-4 inhibitors (7:42)
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SGLT2Section VII - Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors (7:04)
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alpha glucosidaseSection VIII - Alpha-glucosidase Inhibitors (5:02)
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thionamidesSection IX - Thionamides (8:52)
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levothyroxineSection X - Levothyroxine and Liothyronine (4:07)
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cinacalcetSection XI - Cinacalcet (5:25)
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sevelamerSection XII - Sevelamer (3:08)
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ADHSection XIII - ADH-related Drugs (9:28)
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fludrocortisoneSection XIV - Fludrocortisone (2:08)
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Gastrointestinal Pharmacology (13 Videos / Run Time: 1:18:46)
histamine 2Section I - Histamine-2 (H2) Blockers (6:20)
TOPICS: H2 blockers, cimetidine, ranitidine, famotidine, nizatidine, parietal cells, camp, peptic ulcers, gastritis, gerd, antiandrogenic effects, cytochrome p450, confusion, dizziness, headaches, creatinine, adverse effects
Proton pumpSection II - Proton Pump Inhibitors (5:02)
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antacidsSection III - Antacids (9:23)
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bismuthSection IV - Bismuth and Sucralfate (5:00)
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misoprotstolSection V - Misoprostol (3:30)
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octreotideSection VI - Octreotide (7:49)
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sulfasalazineSection VII - Sulfasalazine (4:56)
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loperamideSection VIII - Loperamide and Diphenoxylate (3:39)
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ondansetronSection IX - Ondansetron (6:03)
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metoclopramideSection X - Metoclopramide (7:48)
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orlistatSection XI - Orlistat (3:52)
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laxativesSection XII - Laxatives (13:13)
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aprepitantSection XIII - Aprepitant (2:11)
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Hem/Onc Pharmacology (19 Videos / Run Time: 5:14:55)
heparin fondaparinux mnemonicSection I - Heparin, LMWHs, and Fondaparinux (24:36)
TOPICS: Heparin, anticoagulant, antithrombin III, factor IIa, thrombin, factor Xa, ptt, low molecular weight heparin, lmwh, enoxaparin, dalteparin, fibrin meshwork, fondaparinux, synthetic heparin, renally excreted, bioavailability, half life, pulmonary embolism, acute coronary syndromes, deep venous thrombosis, myocardial infarction, pregnancy, bleeding, thrombocytopenia, hit, platelet count, osteoporosis, protamine sulfate, severe uncontrolled hypertension, uncontrolled active bleed, kidney disease
Direct Thrombin mnemonicSection II - Direct Thrombin Inhibitors and Direct Factor Xa Inhibitors (16:37)
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Warfarin mnemonicSection III - Warfarin (33:25)
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Thrombolytics mnemonicSection IV - Thrombolytics (13:31)
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ADP Receptor Inhibitors mnemonicSection V - ADP Receptor Inhibitors (11:26)
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Antiplatelet PDE mnemonicSection VI - Antiplatelet PDE Inhibitors (Cilastazol and Dipyridamole) (16:45)
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Glycoprotein mnemonicSection VII - Glycoprotein IIb/IIIa Inhibitors (8:18)
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Bleomycin Dactinomycin Doxorubicin and Daunorubicin mnemonicSection VIII - Bleomycin, Dactinomycin, Doxorubicin and Daunorubicin (20:50)
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Cladribine and Cytarabine mnemonicSection IX - Cladribine and Cytarabine (14:16)
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5-Fluorouracil Methotrexate Leucovorin and Hydroxyurea mnemonicSection X - 5-Fluorouracil, Methotrexate, Leucovorin, and Hydroxyurea (28:08)
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Busulfan Cyclophosphamide Ifosfamide and Nitrosureas mnemonicSection XI - Busulfan, Cyclophosphamide, Ifosfamide, and Nitrosureas (20:43)
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Procarbazine mnemonicSection XII - Procarbazine (8:13)
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Microtubule Inhibitors mnemonicSection XIII - Microtubule Inhibitors (13:48)
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Cisplatin Carboplatin Oxaliplatin mnemonicSection XIV - Cisplatin, Carboplatin, Oxaliplatin (and Amifostine) (10:28)
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Etoposide Teniposide Irinotecan and Topotecan mnemonicSection XV - Etoposide, Teniposide, Irinotecan and Topotecan (15:15)
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Imatinib Dasatinib Nilotinib Erlotinib Dabranefib and Vemurafenib mnemonicSection XVI - Imatinib, Dasatinib, Nilotinib, Erlotinib, Dabranefib, and Vemurafenib (19:10)
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Rituximab Bevacizumab Alemtuzumab Cetuximab Panitumumab and Trastuzumab mnemonicSection XVII - Rituximab, Bevacizumab, Alemtuzumab, Cetuximab, Panitumumab, and Trastuzumab (25:47)
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Bortezomib and Carfilzomib mnemonicSection XVIII - Bortezomib and Carfilzomib (6:48)
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Rasburicase mnemonicSection XIX - Class III Rasburicase (6:51)
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Musculoskeletal Pharmacology (9 Videos / Run Time: 1:18:42)
acetaminophenSection I - Acetaminophen (7:08)
TOPICS: Acetaminophen, cyclooxygenase, pge2, hypothalamus, fever, analgesic, tension headache, anti-inflammatory, osteoarthritis, reye syndrome, hepatic necrosis, toxic tissue byproducts, depleted glutathione, n-acetylcysteine
aspirinSection II - Aspirin (12:15)
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celecoxibSection III - Celecoxib (5:09)
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NSAIDsSection IV - NSAIDs (12:17)
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leflunomideSection V - Leflunomide (4:56)
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bisphosphonatesSection VI - Bisphosphonates (6:51)
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teriparatideSection VII - Teriparatide (5:47)
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goutSection VIII - Acute and Chronic Gout Treatment (15:06)
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TNF alphaSection IX - TNF-alpha Inhibitors (9:13)
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Neuro Pharmacology (25 Videos / Run Time: 4:39:56)
epilepsy ethosuximideSection I - Epilepsy: Ethosuximide (5:12)
TOPICS: Ethosuximide, blocks thalamic voltage gated T type calcium channels, first line for absence seizures, spike and wave pattern, frequency of 2.5-3.5 Hz, fatigue, GI distress, headache, itching (urticaria), Stevens Johnson syndrome
epilepsy lamotrigineSection II - Epilepsy: Lamotrigine, Levetiracetam, Topiramate and Valproic Acid (23:27)
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epilepsy carbamazepineSection III - Epilepsy: Carbamazepine, Phenytoin, Gabapentin, Tiagabine, (28:51)
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barbituratesSection IV - Barbiturates (10:31)
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benzodiazepinesSection V - Benzodiazepines (15:05)
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nonbenzodiazepineSection VI - Nonbenzodiazepine Hypnotics (8:55)
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suvorexantSection VII - Suvorexant (6:18)
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ramelteonSection VIII - Ramelteon (4:02)
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triptansSection IX - Triptans (8:24)
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dopamine agonistsSection X - Dopamine Agonists (9:00)
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carbidopa/levodopaSection XI - Carbidopa/Levodopa, COMT Inhibitors (Entacapone, Tolcapone) (14:07)
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dopamine availabilitySection XII - Dopamine Availability (Amantadine) (4:23)
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alzheimer disease treatmentSection XIII - Alzheimer Disease Treatment (Donepezil, Rivastigmine, Galantamine, Memantine) (6:10)
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riluzoleSection XIV - Riluzole (4:13)
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tetrabenazineSection XV - Tetrabenazine (3:47)
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inhaled anestheticsSection XVI - Inhaled Anesthetics (8:46)
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IV anestheticsSection XVII - IV Anesthetics (23:51)
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local anestheticsSection XVIII - Local Anesthetics (6:04)
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neuromuscular blocking drugsSection XIX - Neuromuscular Blocking Drugs (19:18)
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baclofenSection XX - Baclofen, Tizanidine, and Cyclobenzaprine (6:28)
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opioid clinicalSection XXI - Opioid Clinical Use, Mechanism and Overdose (18:58)
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mixed agonist opioidsSection XXII - Mixed Agonist and Antagonist Opioids (Nalbuphine, Pentazocine, Butorphanol) (9:56)
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tramadolSection XXIII - Tramadol (5:22)
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glaucoma decrease synthesisSection XXIV - Glaucoma: Decrease Aqueous Humor Synthesis (13:59)
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glaucoma increaseSection XXV - Glaucoma: Increase Outflow of Aqueous Humor (14:49)
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Psychiatric Pharmacology (30 Videos / Run Time: 4:11:57)
serotoninSection I - Serotonin Syndrome (5:50)
TOPICS: Serotonin syndrome, 5-HT, caused by any drug that increases serotonin, clonus, hyperreflexia, hypertonia, tremors, seizures, autonomic instability, hyperthermia, diaphoresis, diarrhea, altered mental status, cyproheptadine, 5-HT2 receptor antagonist
neurolepticSection II - Neuroleptic Malignant Syndrome (9:38)
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extrapyramidalSection III - Extrapyramidal Symptoms (including Acute Dystonia) (11:49)
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CNS depressantsSection IV - CNS Depressants Overview (8:12)
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alcoholSection V - Alcohol (13:08)
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CNS stimulantsSection VI - CNS Stimulants Overview (8:00)
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amphetaminesSection VII - Amphetamines and Methylphenidate (12:05)
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caffeineSection VIII - Caffeine (3:37)
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cocaineSection IX - Cocaine (14:20)
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nicotineSection X - Nicotine (6:11)
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LSDSection XI - LSD (2:29)
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marijuanaSection XII - Marijuana (7:10)
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MDMASection XIII - MDMA (7:19)
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PCPSection XIV - PCP (4:40)
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typical antipsychoticSection XV - Typical Antipsychotic (3:57)
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atypical antipsychoticSection XVI - Atypical Antipsychotic (13:17)
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lithiumSection XVII - Lithium (11:20)
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buspironeSection XVIII - Buspirone (4:40)
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SSRIsSection XIX - SSRIs (11:15)
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SNRIsSection XX - SNRIs (9:21)
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tricyclic antidepressantsSection XXI - Tricyclic Antidepressants (12:41)
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monoamineSection XXII - Monoamine Oxidase Inhibitors (12:13)
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bupropionSection XXIII - Bupropion (6:34)
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mirtazapineSection XXIV - Mirtazapine (7:13)
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trazodoneSection XXV - Trazodone (7:13)
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vareniclineSection XXVI - Varenicline (4:50)
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vilazodoneSection XXVII - Vilazodone (6:18)
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vortioxetineSection XXVIII - Vortioxetine (7:41)
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antidepressant discontinuationSection XXIX - Antidepressant Discontinuation Syndrome (3:37)
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opioid withdrawalSection XXX- Opioid Withdrawal, Detoxification and Relapse Prevention (15:19)
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Renal Pharmacology (8 Videos / Run Time: 1:02:54)
mannitolSection I - Mannitol (4:21)
TOPICS: Mannitol, osmotic diuretic, intracranial hypertension, intraocular pressure, pulmonary edema, high or low sodium, dehydration, contraindicated in renal failure, heart failure
acetazolamideSection II - Acetazolamide (7:11)
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loop diureticsSection III - Loop Diuretics and Ethacrynic Acid (12:28)
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thiazideSection IV - Thiazide Diuretics (8:01)
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potassiumSection V - Potassium-sparing Diuretics (10:08)
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ace inhibitorsSection VI - ACE Inhibitors (9:21)
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angiotensin IISection VII - Angiotensin II Receptor Blockers (6:00)
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aliskirenSection VIII - Aliskiren (5:24)
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Reproductive Pharmacology (13 Videos / Run Time: 2:11:50)
leuprolideSection I - Leuprolide, Goserelin and Degarelix (13:10)
TOPICS: Goserelin, leuprolide, gnrh analogs, pulsatile fashion they acts as gnrh agonists, continuous use they act as gnrh antagonists, decreased lh and fsh, low testosterone, leydig cells, decreased estrogen synthesis, granulosa cells, uterine fibroids, endometriosis, precocious puberty, prostatic carcinoma, infertility, hypogonadism, decrease libido, erectile dysfunction, nausea, vomiting, degarelix, gnrh antagonist, hot flashes, liver toxicity
estrogensSection II - Estrogens and Hormone Replacement Therapy (11:49)
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raloxifeneSection III - Raloxifene, Clomiphene, Tamoxifen (12:31)
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aromataseSection IV - Aromatase Inhibitors (5:17)
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progestinsSection V - Progestins & Antiprogestins (13:53)
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contraception IUDsSection VI - Combined Contraception and Copper IUDs (12:04)
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tocolyticsSection VII - Tocolytics (4:22)
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danazolSection VIII - Danazol (6:52)
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testosteroneSection IX - Testosterone, Methyltestosterone (7:32)
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antiandrogensSection X - Antiandrogens (12:40)
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phosphodiesteraseSection XI - Phosphodiesterase type 5 inhibitors (10:22)
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micturition controlSection XII - Micturition Control (14:22)
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minoxidilSection XIII - Minoxidil (6:56)
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Respiratory Pharmacology (8 Videos / Run Time: 1:05:14)
histamine 1 blockersSection I - Histamine-1 Blockers (9:51)
TOPICS: H-1 blockers, first generation H1 blockers, blood brain barrier, more side effects, diphenhydramine, chlorpheniramine, dimenhydrinate, doxylamine, treat allergies, motion sickness, sleep aid, sedation, antimuscarinic effects, anti alpha adrenergic effects, hypotension, tachycardia, second generation H1 blockers, loratadine, fexofenadine, desloratadine, cetirizine, treat allergies, less sedating
dextromethorphanSection II - Dextromethorphan and Guaifenesin (4:25)
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n acetylocysteineSection III - N-acetylcysteine (1:56)
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pseudoephedrineSection IV - Pseudoephedrine, Phenylephrine (11:09)
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pulmonarySection V - Pulmonary HTN Drugs (10:04)
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asthma treatmentSection VI - Asthma Treatment (10:36)
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alternative asthmaSection VII - Alternative Asthma Treatment (12:21)
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monoclonalSection VIII - Anti-IL-5 Monoclonal Therapy (4:52)
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