Pharmacology Fundamentals (8 Videos / Run Time: 1:53:50) |
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Section I - Enzyme Kinetics (16:04) |
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Enzyme kinetics, michaelis-menten plots, reaction velocity, rate of reaction, vmax, enzyme concentration, substrate concentration, km, enzyme affinity, lineweaver-burk plot, competitive inhibitors, noncompetitive inhibitors, binding site, active site, allosteric site
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Section II - Pharmacokinetics and Dosage Calculations (12:44) |
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Section III - Drug Metabolism, Elimination, and Urine pH (11:01) |
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Section IV - Efficacy, Potency, Activity at Cell Receptors, and Therapeutic Index (15:24) |
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Section V - Drug-drug Interactions (7:45) |
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Section VI - Cytochrome P-450 (21:55) |
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Section VII - Beers Criteria (11:35) |
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Section VIII - Seafood Toxins (17:22) |
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Autonomic Pharmacology (14 Videos / Run Time: 4:12:18) |
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Section I - Adrenergic Receptors (26:05) |
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Alpha-1 receptors, gpcr, gq protein, phospholipase c activation, pip2, ip3, dag, pkc, calcium, pupillary dilator muscle contraction, mydriasis (dilated pupils), alpha-1 stimulation, vascular smooth muscle contraction, vasoconstriction, internal urethral sphincter muscle contraction, alpha-2 receptors, gq protein, adenylate cyclase, camp, norepinephrine (ne) release, aqueous humor production, intraocular pressure, insulin release, lipolysis, platelet aggregation, beta1, beta2, beta3, gs protein, contractility, inotropy, inotropic, chronotropy,chronotropic, renin, lipolysis, vasodilation, skeletal muscle, coronary arteries, bronchodilation/bronchial relaxation, potassium, glycogenolysis, uterine tone, detrusor smooth muscle, bladder capacity, thermogenesis
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Section II - Epinephrine and Norepinephrine (25:19) |
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Section III - Alpha Agonists (18:16) |
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Section IV - Beta Agonists (16:47) |
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Section V - Alpha Blockers (20:21) |
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Section VI - Beta Blockers (19:03) |
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Section VII - Nicotinic Acetylcholine Receptors (7:35) |
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Section VIII - Muscarinic Acetylcholine Receptors (15:28) |
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Section IX - Direct Cholinergic Agonists (19:59) |
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Section X - Indirect Cholinergic Agonists (20:44) |
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Section XI - Anticholinesterase Poisoning (16:14) |
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Section XII - Muscarinic Antagonists (12:53) |
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Section XIII - Atropine (14:02) |
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Section XIV - Dopamine, Histamine, and Vasopressin Receptors(19:32) |
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Immunology Pharmacology (9 Videos / Run Time: 1:11:29) |
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Section I - Cyclosporine (7:36) |
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TOPICS:
Cyclosporine, cyclophilin, calcineurin, immunomodulator, blocks t-cell, blocks IL-2 gene, block transcription, rheumatoid arthritis, treatment, psoriasis, acute transplant rejection, gingival hyperplasia, hypertension, gout, risk of infection, risk of malignancy, hyperlipidemia, neurotoxicity, tremor, nephrotoxicity, renal tubular acidosis, RTA
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Section II - Tacrolimus (4:57) |
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Section III - Sirolimus (7:47) |
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Section IV - Basiliximab (4:03) |
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Section V - Azathioprine and 6 MP (11:26) |
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Section VI - Mycophenolate (5:27) |
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Section VII - Glucocorticoids (14:56) |
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Section VIII - Bone Marrow Stimulation (6:38) |
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Section IX - Interferons Alpha, Beta and Gamma (8:39) |
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Antibiotics (24 Videos / Run Time: 3:22:13) |
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Section I - Penicillin G,V (9:43) |
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TOPICS:
Penicillin, beta lactam rings, pbp, penicillin binding proteins, cell wall cross linking, peptidoglycan, resistance, beta lactamases, syphilis, actinomyces, neisseria meningitidis, strep agalactiae, intrapartum period, rheumatic fever, strep pyogenes, m protein, strep pharyngitis, strep pneumoniae, hypersensitivity, autoimmune hemolytic anemia, allergic reactions, acute interstitial nephritis, serum sickness, stevens johnson syndrome
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Section II - Amoxicillin and Ampicillin (11:17) |
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Section III - Antistaphylococcal Penicillins (5:19) |
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Section IV - Antipseudomonal Penicillins (8:02) |
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Section V - Cephalosporins (18:18) |
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Section VI - Carbapenems (6:42) |
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Section VII - Monobactams (6:16) |
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Section VIII - Vancomycin (10:38) |
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Section IX - Bacitracin (2:33) |
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Section X - Aminoglycosides (9:55) |
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Section XI - Tetracyclines (9:41) |
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Section XII - Glycylcyclines (5:37) |
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Section XIII - Chloramphenicol (9:08) |
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Section XIV - Clindamycin (7:37) |
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Section XV - Linezolid (4:42) |
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Section XVI - Macrolides (11:44) |
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Section XVII - Polymyxins (4:57) |
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Section XVIII - Trimethoprim and Sulfonamides (12:34) |
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Section XIX - Fluoroquinolones (8:14) |
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Section XX - Daptomycin (5:46) |
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Section XXI - Metronidazole (5:59) |
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Section XXII - Dapsone, Rifamycins, Clofazimine (Leprosy Drugs) (11:27) |
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Section XXIII - Isoniazid (RIPE) (9:18) |
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Section XXIV - Ethambutol and Pyrazinamide (6:46) |
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Antifungals (5 Videos / Run Time: 0:37:51) |
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Section I - Amphotericin B, Nystatin, and Flucytosine (13:09) |
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TOPICS:
Amphotericin b, ergosterol, electrolyte leakage, cryptococcus, flucytosine, 5 fluorouracil, bone marrow suppression, intrathecal, meningitis, coccidioidomycosis, blastomycosis, histoplasmosis, candida, mucor, human cholesterol, fever, chills, kidney damage, hydrated, magnesium, potassium, arrhythmia, anemia, hypotension, liposomal, thrombophlebitis, nystatin, candida, topical, esophageal and oral candidiasis
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Section II - Azoles (11:23) |
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Section III - Terbinafine (3:47) |
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Section IV - Echinocandins (3:44) |
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Section V - Griseofulvin (5:48) |
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Antiparasitic Drugs (1 Video / Run Time: 0:05:46) |
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Section I - Malathion, Permethrin, and Lindane (5:46) |
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Neuronal synapse, acetylcholinesterase, malathion, neurotoxicity, conjunctivitis, permethrin, sodium channel, lindane, gaba, ataxia, burning sensation, pediculus infections, lice, scabies
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Antivirals (10 Videos / Run Time: 1:03:34) |
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Section I - Oseltamivir and Zanamivir (2:31) |
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Oseltamivir, Zanamivir, antiviral, Tamiflu, inhibit neuraminidase, decreased release of viral progeny, influenza A, influenza B, within 48 hours, decrease illness duration
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Section II - Acyclovir, Valacyclovir, and Famciclovir (7:53) |
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Section III - Ganciclovir and Valganciclovir (6:08) |
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Section IV - Foscarnet and Cidofovir (7:18) |
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Section V - NRTIs (9:22) |
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Section VI - NNRTIs (5:53) |
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Section VII - Protease Inhibitors (7:34) |
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Section VIII - Integrase Inhibitors (4:43) |
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Section IX - Fusion Inhibitors (6:28) |
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Section X - Hepatitis C Therapy (5:44) |
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Cardiac Pharmacology (22 Videos / Run Time: 4:02:18) |
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Section I - Hypertension Treatment (17:39) |
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TOPICS:
Primary hypertension, essential hypertension, thiazide, ace inhibitors, angiotensin receptor blockers, calcium channel blockers, asthma, cough, bronchoconstriction, cardioselective beta blockers, diabetes mellitus, D diabetic nephropathy, hypoglycemia, pregnancy, hydralazine, labetalol, methyldopa, nifedipine, heart failure, loop diuretics, sacubitril, cardiogenic shock, decompensated heart failure, aldosterone antagonists
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Section II - Calcium Channel Blockers (13:37) |
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Section III - Hydralazine (8:19) |
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Section IV - Fenoldopam and Nitroprusside (9:50) |
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Section V - Nitrates (13:13) |
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Section VI - Ranolazine (4:32) |
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Section VII - Milrinone (6:19) |
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Section VIII - Sacubitril (8:49) |
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Section IX - Statins (8:36) |
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Section X - Bile Acid Resins (6:56) |
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Section XI - Ezetimibe (3:50) |
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Section XII - Fibrates (9:02) |
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Section XIII - Niacin (7:57) |
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Section XIV - PCSK9 Inhibitors (6:22) |
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Section XV - Fish Oil, and Omega-3 Fatty Acids (3:57) |
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Section XVI - Digoxin (12:52) |
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Section XVII - Class IA, IB, and IC Antiarrhythmics (23:51) |
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Section XVIII - Class II Antiarrhythmics (23:08) |
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Section XIX - Class III Antiarrhythmics (16:28) |
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Section XX - Class IV Antiarrhythmics (14:18) |
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Section XXI - Other Antiarrhythmics (Adenosine and Magnesium) (15:25) |
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Section XXII - Ivabradine (7:18) |
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Endocrine Pharmacology (14 Videos / Run Time: 1:30:23) |
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Section I - Insulin Preparations (8:16) |
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TOPICS:
Regular insulin, 2-3 hour peak, diabetic ketoacidosis, hyperkalemia, stress hyperglycemia, rapid acting preparations, 1 hour peak, lispro, aspart, glulisine, nph, intermediary acting, 4-10 hour peak, long acting preparations, detemir, glargine, insulin receptor, tyrosine kinase receptor, glycogen, protein synthesis, triglyceride storage, potassium, hypoglycemia, lipodystrophy, weight gain, hypersensitivity
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Section II - Biguanides (Metformin) (7:05) |
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Section III - Glitazones/Thiazolidinediones (7:13) |
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Section IV - Sulfonylureas and Meglitinides (7:36) |
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Section V - Amylin analogs and GLP-1 analogs (7:17) |
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Section VI - DPP-4 inhibitors (7:42) |
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Section VII - Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors (7:04) |
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Section VIII - Alpha-glucosidase Inhibitors (5:02) |
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Section IX - Thionamides (8:52) |
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Section X - Levothyroxine and Liothyronine (4:07) |
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Section XI - Cinacalcet (5:25) |
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Section XII - Sevelamer (3:08) |
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Section XIII - ADH-related Drugs (9:28) |
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Section XIV - Fludrocortisone (2:08) |
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Gastrointestinal Pharmacology (13 Videos / Run Time: 1:18:46) |
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Section I - Histamine-2 (H2) Blockers (6:20) |
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TOPICS:
H2 blockers, cimetidine, ranitidine, famotidine, nizatidine, parietal cells, camp, peptic ulcers, gastritis, gerd, antiandrogenic effects, cytochrome p450, confusion, dizziness, headaches, creatinine, adverse effects
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Section II - Proton Pump Inhibitors (5:02) |
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Section III - Antacids (9:23) |
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Section IV - Bismuth and Sucralfate (5:00) |
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Section V - Misoprostol (3:30) |
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Section VI - Octreotide (7:49) |
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Section VII - Sulfasalazine (4:56) |
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Section VIII - Loperamide and Diphenoxylate (3:39) |
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Section IX - Ondansetron (6:03) |
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Section X - Metoclopramide (7:48) |
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Section XI - Orlistat (3:52) |
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Section XII - Laxatives (13:13) |
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Section XIII - Aprepitant (2:11) |
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Hem/Onc Pharmacology (19 Videos / Run Time: 5:14:55) |
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Section I - Heparin, LMWHs, and Fondaparinux (24:36) |
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TOPICS:
Heparin, anticoagulant, antithrombin III, factor IIa, thrombin, factor Xa, ptt, low molecular weight heparin, lmwh, enoxaparin, dalteparin, fibrin meshwork, fondaparinux, synthetic heparin, renally excreted, bioavailability, half life, pulmonary embolism, acute coronary syndromes, deep venous thrombosis, myocardial infarction, pregnancy, bleeding, thrombocytopenia, hit, platelet count, osteoporosis, protamine sulfate, severe uncontrolled hypertension, uncontrolled active bleed, kidney disease
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Section II - Direct Thrombin Inhibitors and Direct Factor Xa Inhibitors (16:37) |
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Section III - Warfarin (33:25) |
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Section IV - Thrombolytics (13:31) |
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Section V - ADP Receptor Inhibitors (11:26) |
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Section VI - Antiplatelet PDE Inhibitors (Cilastazol and Dipyridamole) (16:45) |
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Section VII - Glycoprotein IIb/IIIa Inhibitors (8:18) |
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Section VIII - Bleomycin, Dactinomycin, Doxorubicin and Daunorubicin (20:50) |
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Section IX - Cladribine and Cytarabine (14:16) |
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Section X - 5-Fluorouracil, Methotrexate, Leucovorin, and Hydroxyurea (28:08) |
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Section XI - Busulfan, Cyclophosphamide, Ifosfamide, and Nitrosureas (20:43) |
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Section XII - Procarbazine (8:13) |
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Section XIII - Microtubule Inhibitors (13:48) |
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Section XIV - Cisplatin, Carboplatin, Oxaliplatin (and Amifostine) (10:28) |
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Section XV - Etoposide, Teniposide, Irinotecan and Topotecan (15:15) |
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Section XVI - Imatinib, Dasatinib, Nilotinib, Erlotinib, Dabranefib, and Vemurafenib (19:10) |
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Section XVII - Rituximab, Bevacizumab, Alemtuzumab, Cetuximab, Panitumumab, and Trastuzumab (25:47) |
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Section XVIII - Bortezomib and Carfilzomib (6:48) |
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Section XIX - Rasburicase (6:51) |
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Musculoskeletal Pharmacology (9 Videos / Run Time: 1:18:42) |
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Section I - Acetaminophen (7:08) |
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Acetaminophen, cyclooxygenase, pge2, hypothalamus, fever, analgesic, tension headache, anti-inflammatory, osteoarthritis, hepatic necrosis, toxic tissue byproducts, depleted glutathione, n-acetylcysteine
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Section II - Aspirin (12:15) |
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Section III - Celecoxib (5:09) |
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Section IV - NSAIDs (12:17) |
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Section V - Leflunomide (4:56) |
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Section VI - Bisphosphonates (6:51) |
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Section VII - Teriparatide (5:47) |
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Section VIII - Acute and Chronic Gout Treatment (15:06) |
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Section IX - TNF-alpha Inhibitors (9:13) |
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Neuro Pharmacology (25 Videos / Run Time: 4:39:56) |
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Section I - Epilepsy: Ethosuximide (5:12) |
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Ethosuximide, blocks thalamic voltage gated T type calcium channels, first line for absence seizures, spike and wave pattern, frequency of 2.5-3.5 Hz, fatigue, GI distress, headache, itching (urticaria), Stevens Johnson syndrome
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Section II - Epilepsy: Lamotrigine, Levetiracetam, Topiramate and Valproic Acid (23:27) |
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Section III - Epilepsy: Carbamazepine, Phenytoin, Gabapentin, Tiagabine, (28:51) |
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Section IV - Barbiturates (10:31) |
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Section V - Benzodiazepines (15:05) |
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Section VI - Nonbenzodiazepine Hypnotics (8:55) |
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Section VII - Suvorexant (6:18) |
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Section VIII - Ramelteon (4:02) |
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Section IX - Triptans (8:24) |
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Section X - Dopamine Agonists (9:00) |
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Section XI - Carbidopa/Levodopa, COMT Inhibitors (Entacapone, Tolcapone) (14:07) |
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Section XII - Dopamine Availability (Amantadine) (4:23) |
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Section XIII - Alzheimer Disease Treatment (Donepezil, Rivastigmine, Galantamine, Memantine) (6:10) |
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Section XIV - Riluzole (4:13) |
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Section XV - Tetrabenazine (3:47) |
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Section XVI - Inhaled Anesthetics (8:46) |
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Section XVII - IV Anesthetics (13:39) |
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Section XVIII - Local Anesthetics (16:35) |
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Section XIX - Neuromuscular Blocking Drugs (19:18) |
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Section XX - Baclofen, Tizanidine, and Cyclobenzaprine (6:28) |
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Section XXI - Opioid Clinical Use, Mechanism and Overdose (18:58) |
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Section XXII - Mixed Agonist and Antagonist Opioids (Nalbuphine, Pentazocine, Butorphanol) (9:56) |
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Section XXIII - Tramadol (5:22) |
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Section XXIV - Glaucoma: Decrease Aqueous Humor Synthesis (13:59) |
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Section XXV - Glaucoma: Increase Outflow of Aqueous Humor (14:49) |
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Psychiatric Pharmacology (30 Videos / Run Time: 4:11:57) |
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Section I - Serotonin Syndrome (5:50) |
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Serotonin syndrome, 5-HT, caused by any drug that increases serotonin, clonus, hyperreflexia, hypertonia, tremors, seizures, autonomic instability, hyperthermia, diaphoresis, diarrhea, altered mental status, cyproheptadine, 5-HT2 receptor antagonist
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Section II - Neuroleptic Malignant Syndrome (9:38) |
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Section III - Extrapyramidal Symptoms (including Acute Dystonia) (11:49) |
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Section IV - CNS Depressants Overview (8:12) |
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Section V - Alcohol (13:08) |
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Section VI - CNS Stimulants Overview (8:00) |
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Section VII - Amphetamines and Methylphenidate (12:05) |
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Section VIII - Caffeine (3:37) |
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Section IX - Cocaine (14:20) |
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Section X - Nicotine (6:11) |
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Section XI - LSD (2:29) |
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Section XII - Marijuana (7:10) |
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Section XIII - MDMA (7:19) |
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Section XIV - PCP (4:40) |
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Section XV - Typical Antipsychotic (13:57) |
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Section XVI - Atypical Antipsychotic (13:17) |
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Section XVII - Lithium (11:20) |
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Section XVIII - Buspirone (4:40) |
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Section XIX - SSRIs (11:15) |
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Section XX - SNRIs (9:21) |
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Section XXI - Tricyclic Antidepressants (12:41) |
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Section XXII - Monoamine Oxidase Inhibitors (12:13) |
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Section XXIII - Bupropion (6:34) |
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Section XXIV - Mirtazapine (7:13) |
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Section XXV - Trazodone (7:13) |
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Section XXVI - Varenicline (4:50) |
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Section XXVII - Vilazodone (6:18) |
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Section XXVIII - Vortioxetine (7:41) |
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Section XXIX - Antidepressant Discontinuation Syndrome (3:37) |
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Section XXX- Opioid Withdrawal, Detoxification and Relapse Prevention (15:19) |
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Renal Pharmacology (8 Videos / Run Time: 1:02:54) |
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Section I - Mannitol (4:21) |
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Mannitol, osmotic diuretic, intracranial hypertension, intraocular pressure, pulmonary edema, high or low sodium, dehydration, contraindicated in renal failure, heart failure
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Section II - Acetazolamide (7:11) |
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Section III - Loop Diuretics and Ethacrynic Acid (12:28) |
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Section IV - Thiazide Diuretics (8:01) |
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Section V - Potassium-sparing Diuretics (10:08) |
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Section VI - ACE Inhibitors (9:21) |
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Section VII - Angiotensin II Receptor Blockers (6:00) |
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Section VIII - Aliskiren (5:24) |
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Reproductive Pharmacology (13 Videos / Run Time: 2:11:50) |
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Section I - Leuprolide, Goserelin and Degarelix (13:10) |
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TOPICS:
Goserelin, leuprolide, gnrh analogs, pulsatile fashion they acts as gnrh agonists, continuous use they act as gnrh antagonists, decreased lh and fsh, low testosterone, leydig cells, decreased estrogen synthesis, granulosa cells, uterine fibroids, endometriosis, precocious puberty, prostatic carcinoma, infertility, hypogonadism, decrease libido, erectile dysfunction, nausea, vomiting, degarelix, gnrh antagonist, hot flashes, liver toxicity
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Section II - Estrogens and Hormone Replacement Therapy (11:49) |
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Section III - Raloxifene, Clomiphene, Tamoxifen (12:31) |
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Section IV - Aromatase Inhibitors (5:17) |
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Section V - Progestins & Antiprogestins (13:53) |
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Section VI - Combined Contraception and Copper IUDs (12:04) |
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Section VII - Tocolytics (4:22) |
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Section VIII - Danazol (6:52) |
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Section IX - Testosterone, Methyltestosterone (7:32) |
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Section X - Antiandrogens (12:40) |
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Section XI - Phosphodiesterase type 5 inhibitors (10:22) |
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Section XII - Micturition Control (14:22) |
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Section XIII - Minoxidil (6:56) |
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Respiratory Pharmacology (8 Videos / Run Time: 1:05:14) |
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Section I - Histamine-1 Blockers (9:51) |
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TOPICS:
H-1 blockers, first generation H1 blockers, blood brain barrier, more side effects, diphenhydramine, chlorpheniramine, dimenhydrinate, doxylamine, treat allergies, motion sickness, sleep aid, sedation, antimuscarinic effects, anti alpha adrenergic effects, hypotension, tachycardia, second generation H1 blockers, loratadine, fexofenadine, desloratadine, cetirizine, treat allergies, less sedating
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Section II - Dextromethorphan and Guaifenesin (4:25) |
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Section III - N-acetylcysteine (1:56) |
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Section IV - Pseudoephedrine, Phenylephrine (11:09) |
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Section V - Pulmonary HTN Drugs (10:04) |
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Section VI - Asthma Treatment (10:36) |
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Section VII - Alternative Asthma Treatment (12:10) |
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Section VIII - Anti-IL-5 Monoclonal Therapy (4:52) |
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