Pharmacology

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☐	Section 1 - Enzyme Kinetics (16:04)
TOPICS: Enzyme kinetics, michaelis-menten plots, reaction velocity, rate of reaction, vmax, enzyme concentration, substrate concentration, km, enzyme affinity, lineweaver-burk plot, competitive inhibitors, noncompetitive inhibitors, binding site, active site, allosteric site
☐	Section 2 - Pharmacokinetics and Dosage Calculations (12:44)
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☐	Section 3 - Drug Metabolism, Elimination, and Urine pH (11:01)
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☐	Section 4 - Efficacy, Potency, Activity at Cell Receptors, and Therapeutic Index (15:24)
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☐	Section 5 - Drug-drug Interactions (7:45)
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☐	Section 6 - Cytochrome P-450 (21:55)
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☐	Section 7 - Beers Criteria (11:35)
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☐	Section 8 - Seafood Toxins (17:22)
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☐	Section 1 - Adrenergic Receptors (26:05)
TOPICS: Alpha-1 receptors, gpcr, gq protein, phospholipase c activation, pip2, ip3, dag, pkc, calcium, pupillary dilator muscle contraction, mydriasis (dilated pupils), alpha-1 stimulation, vascular smooth muscle contraction, vasoconstriction, internal urethral sphincter muscle contraction, alpha-2 receptors, gq protein, adenylate cyclase, camp, norepinephrine (ne) release, aqueous humor production, intraocular pressure, insulin release, lipolysis, platelet aggregation, beta1, beta2, beta3, gs protein, contractility, inotropy, inotropic, chronotropy,chronotropic, renin, lipolysis, vasodilation, skeletal muscle, coronary arteries, bronchodilation/bronchial relaxation, potassium, glycogenolysis, uterine tone, detrusor smooth muscle, bladder capacity, thermogenesis
☐	Section 2 - Epinephrine and Norepinephrine (25:19)
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☐	Section 3 - Alpha Agonists (18:16)
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☐	Section 4 - Beta Agonists (16:47)
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☐	Section 5 - Alpha Blockers (20:21)
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☐	Section 6 - Beta Blockers (19:03)
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☐	Section 7 - Nicotinic Acetylcholine Receptors (7:35)
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☐	Section 8 - Muscarinic Acetylcholine Receptors (15:28)
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☐	Section 9 - Direct Cholinergic Agonists (19:59)
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☐	Section 10 - Indirect Cholinergic Agonists (20:44)
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☐	Section 11 - Anticholinesterase Poisoning (16:14)
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☐	Section 12 - Muscarinic Antagonists (12:53)
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☐	Section 13 - Atropine (14:02)
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☐	Section 14 - Dopamine, Histamine, and Vasopressin Receptors(19:32)
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☐	Section 1 - Cyclosporine (7:36)
TOPICS: Cyclosporine, cyclophilin, calcineurin, immunomodulator, blocks t-cell, blocks IL-2 gene, block transcription, rheumatoid arthritis, treatment, psoriasis, acute transplant rejection, gingival hyperplasia, hypertension, gout, risk of infection, risk of malignancy, hyperlipidemia, neurotoxicity, tremor, nephrotoxicity, renal tubular acidosis, RTA
☐	Section 2 - Tacrolimus (4:57)
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☐	Section 3 - Sirolimus (7:47)
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☐	Section 4 - Basiliximab (4:03)
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☐	Section 5 - Azathioprine and 6 MP (11:26)
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☐	Section 6 - Mycophenolate (5:27)
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☐	Section 7 - Glucocorticoids (14:56)
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☐	Section 8 - Bone Marrow Stimulation (6:38)
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☐	Section 9 - Interferons Alpha, Beta and Gamma (8:39)
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☐	Section 1 - Penicillin G,V (9:43)
TOPICS: Penicillin, beta lactam rings, pbp, penicillin binding proteins, cell wall cross linking, peptidoglycan, resistance, beta lactamases, syphilis, actinomyces, neisseria meningitidis, strep agalactiae, intrapartum period, rheumatic fever, strep pyogenes, m protein, strep pharyngitis, strep pneumoniae, hypersensitivity, autoimmune hemolytic anemia, allergic reactions, acute interstitial nephritis, serum sickness, stevens johnson syndrome
☐	Section 2 - Amoxicillin and Ampicillin (11:17)
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☐	Section 3 - Antistaphylococcal Penicillins (5:19)
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☐	Section 4 - Antipseudomonal Penicillins (8:02)
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☐	Section 5 - Cephalosporins (18:18)
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☐	Section 6 - Carbapenems (6:42)
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☐	Section 7 - Monobactams (6:16)
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☐	Section 8 - Vancomycin (10:38)
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☐	Section 9 - Bacitracin (2:33)
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☐	Section 10 - Aminoglycosides (9:55)
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☐	Section 11 - Tetracyclines (9:41)
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☐	Section 12 - Glycylcyclines (5:37)
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☐	Section 13 - Chloramphenicol (9:08)
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☐	Section 14 - Clindamycin (7:37)
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☐	Section 15 - Linezolid (4:42)
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☐	Section 16 - Macrolides (11:44)
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☐	Section 17 - Polymyxins (4:57)
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☐	Section 18- Trimethoprim and Sulfonamides (12:34)
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☐	Section 19 - Fluoroquinolones (8:14)
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☐	Section 20 - Daptomycin (5:46)
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☐	Section 21 - Metronidazole (5:59)
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☐	Section 22 - Dapsone, Rifamycins, Clofazimine (Leprosy Drugs) (11:27)
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☐	Section 23 - Isoniazid (RIPE) (9:18)
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☐	Section 24 - Ethambutol and Pyrazinamide (6:46)
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☐	Section 1 - Amphotericin B, Nystatin, and Flucytosine (13:09)
TOPICS: Amphotericin b, ergosterol, electrolyte leakage, cryptococcus, flucytosine, 5 fluorouracil, bone marrow suppression, intrathecal, meningitis, coccidioidomycosis, blastomycosis, histoplasmosis, candida, mucor, human cholesterol, fever, chills, kidney damage, hydrated, magnesium, potassium, arrhythmia, anemia, hypotension, liposomal, thrombophlebitis, nystatin, candida, topical, esophageal and oral candidiasis
☐	Section 2 - Azoles (11:23)
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☐	Section 3 - Terbinafine (3:47)
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☐	Section 4 - Echinocandins (3:44)
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☐	Section 5 - Griseofulvin (5:48)
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☐	Section 1 - Malathion, Permethrin, and Lindane (5:46)
TOPICS: Neuronal synapse, acetylcholinesterase, malathion, neurotoxicity, conjunctivitis, permethrin, sodium channel, lindane, gaba, ataxia, burning sensation, pediculus infections, lice, scabies

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☐	Section 1 - Oseltamivir and Zanamivir (2:31)
TOPICS: Oseltamivir, Zanamivir, antiviral, Tamiflu, inhibit neuraminidase, decreased release of viral progeny, influenza A, influenza B, within 48 hours, decrease illness duration
☐	Section 2 - Acyclovir, Valacyclovir, and Famciclovir (7:53)
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☐	Section 3 - Ganciclovir and Valganciclovir (6:08)
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☐	Section 4 - Foscarnet and Cidofovir (7:18)
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☐	Section 5 - NRTIs (9:22)
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☐	Section 6 - NNRTIs (5:53)
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☐	Section 7 - Protease Inhibitors (7:34)
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☐	Section 8 - Integrase Inhibitors (4:43)
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☐	Section 9 - Fusion Inhibitors (6:28)
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☐	Section 10 - Hepatitis C Therapy (5:44)
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☐	Section 1 - Hypertension Treatment (17:39)
TOPICS: Primary hypertension, essential hypertension, thiazide, ace inhibitors, angiotensin receptor blockers, calcium channel blockers, asthma, cough, bronchoconstriction, cardioselective beta blockers, diabetes mellitus, D diabetic nephropathy, hypoglycemia, pregnancy, hydralazine, labetalol, methyldopa, nifedipine, heart failure, loop diuretics, sacubitril, cardiogenic shock, decompensated heart failure, aldosterone antagonists
☐	Section 2 - Calcium Channel Blockers (13:37)
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☐	Section 3 - Hydralazine (8:19)
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☐	Section 4 - Fenoldopam and Nitroprusside (9:50)
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☐	Section 5 - Nitrates (13:13)
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☐	Section 6 - Ranolazine (4:32)
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☐	Section 7 - Milrinone (6:19)
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☐	Section 8 - Sacubitril (8:49)
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☐	Section 9 - Statins (8:36)
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☐	Section 10 - Bile Acid Resins (6:56)
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☐	Section 11 - Ezetimibe (3:50)
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☐	Section 12 - Fibrates (9:02)
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☐	Section 13 - Niacin (7:57)
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☐	Section 14 - PCSK9 Inhibitors (6:22)
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☐	Section 15 - Fish Oil, and Omega-3 Fatty Acids (3:57)
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☐	Section 16 - Digoxin (12:52)
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☐	Section 17 - Class IA, IB, and IC Antiarrhythmics (23:51)
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☐	Section 18 - Class II Antiarrhythmics (23:08)
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☐	Section 19 - Class III Antiarrhythmics (16:28)
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☐	Section 20 - Class IV Antiarrhythmics (14:18)
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☐	Section 21 - Other Antiarrhythmics (Adenosine and Magnesium) (15:25)
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☐	Section 22 - Ivabradine (7:18)
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☐	Section 1 - Insulin Preparations (8:16)
TOPICS: Regular insulin, 2-3 hour peak, diabetic ketoacidosis, hyperkalemia, stress hyperglycemia, rapid acting preparations, 1 hour peak, lispro, aspart, glulisine, nph, intermediary acting, 4-10 hour peak, long acting preparations, detemir, glargine, insulin receptor, tyrosine kinase receptor, glycogen, protein synthesis, triglyceride storage, potassium, hypoglycemia, lipodystrophy, weight gain, hypersensitivity
☐	Section 2 - Biguanides (Metformin) (7:05)
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☐	Section 3 - Glitazones/Thiazolidinediones (7:13)
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☐	Section 4 - Sulfonylureas and Meglitinides (7:36)
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☐	Section 5 - Amylin analogs and GLP-1 analogs (7:17)
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☐	Section 6 - DPP-4 inhibitors (7:42)
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☐	Section 7 - Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors (7:04)
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☐	Section 8 - Alpha-glucosidase Inhibitors (5:02)
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☐	Section 9 - Thionamides (8:52)
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☐	Section 10 - Levothyroxine and Liothyronine (4:07)
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☐	Section 11 - Cinacalcet (5:25)
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☐	Section 12 - Sevelamer (3:08)
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☐	Section 13 - ADH-related Drugs (9:28)
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☐	Section 14 - Fludrocortisone (2:08)
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☐	Section 1 - Histamine-2 (H2) Blockers (6:20)
TOPICS: H2 blockers, cimetidine, ranitidine, famotidine, nizatidine, parietal cells, camp, peptic ulcers, gastritis, gerd, antiandrogenic effects, cytochrome p450, confusion, dizziness, headaches, creatinine, adverse effects
☐	Section 2 - Proton Pump Inhibitors (5:02)
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☐	Section 3 - Antacids (9:23)
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☐	Section 4 - Bismuth and Sucralfate (5:00)
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☐	Section 5 - Misoprostol (3:30)
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☐	Section 6 - Octreotide (7:49)
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☐	Section 7 - Sulfasalazine (4:56)
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☐	Section 8 - Loperamide and Diphenoxylate (3:39)
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☐	Section 9 - Ondansetron (6:03)
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☐	Section 10 - Metoclopramide (7:48)
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☐	Section 11 - Orlistat (3:52)
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☐	Section 12 - Laxatives (13:13)
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☐	Section 13 - Aprepitant (2:11)
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☐	Section 1 - Heparin, LMWHs, and Fondaparinux (24:36)
TOPICS: Heparin, anticoagulant, antithrombin III, factor IIa, thrombin, factor Xa, ptt, low molecular weight heparin, lmwh, enoxaparin, dalteparin, fibrin meshwork, fondaparinux, synthetic heparin, renally excreted, bioavailability, half life, pulmonary embolism, acute coronary syndromes, deep venous thrombosis, myocardial infarction, pregnancy, bleeding, thrombocytopenia, hit, platelet count, osteoporosis, protamine sulfate, severe uncontrolled hypertension, uncontrolled active bleed, kidney disease
☐	Section 2 - Direct Thrombin Inhibitors and Direct Factor Xa Inhibitors (16:37)
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☐	Section 3 - Warfarin (33:25)
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☐	Section 4 - Thrombolytics (13:31)
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☐	Section 5 - ADP Receptor Inhibitors (11:26)
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☐	Section 6 - Antiplatelet PDE Inhibitors (Cilastazol and Dipyridamole) (16:45)
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☐	Section 7 - Glycoprotein IIb/IIIa Inhibitors (8:18)
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☐	Section 8 - Bleomycin, Dactinomycin, Doxorubicin and Daunorubicin (20:50)
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☐	Section 9 - Cladribine and Cytarabine (14:16)
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☐	Section 10 - 5-Fluorouracil, Methotrexate, Leucovorin, and Hydroxyurea (28:08)
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☐	Section 11 - Busulfan, Cyclophosphamide, Ifosfamide, and Nitrosureas (20:43)
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☐	Section 12 - Procarbazine (8:13)
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☐	Section 13 - Microtubule Inhibitors (13:48)
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☐	Section 14 - Cisplatin, Carboplatin, Oxaliplatin (and Amifostine) (10:28)
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☐	Section 15 - Etoposide, Teniposide, Irinotecan and Topotecan (15:15)
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☐	Section 16 - Imatinib, Dasatinib, Nilotinib, Erlotinib, Dabranefib, and Vemurafenib (19:10)
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☐	Section 17 - Rituximab, Bevacizumab, Alemtuzumab, Cetuximab, Panitumumab, and Trastuzumab (25:47)
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☐	Section 18 - Bortezomib and Carfilzomib (6:48)
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☐	Section 19 - Rasburicase (6:51)
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☐	Section 1 - Acetaminophen (7:08)
TOPICS: Acetaminophen, cyclooxygenase, pge2, hypothalamus, fever, analgesic, tension headache, anti-inflammatory, osteoarthritis, hepatic necrosis, toxic tissue byproducts, depleted glutathione, n-acetylcysteine
☐	Section 2 - Aspirin (12:15)
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☐	Section 3 - Celecoxib (5:09)
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☐	Section 4 - NSAIDs (12:17)
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☐	Section 5 - Leflunomide (4:56)
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☐	Section 6 - Bisphosphonates (6:51)
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☐	Section 7 - Teriparatide (5:47)
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☐	Section 8 - Acute and Chronic Gout Treatment (15:06)
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☐	Section 9 - TNF-alpha Inhibitors (9:13)
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☐	Section 1 - Epilepsy: Ethosuximide (5:12)
TOPICS: Ethosuximide, blocks thalamic voltage gated T type calcium channels, first line for absence seizures, spike and wave pattern, frequency of 2.5-3.5 Hz, fatigue, GI distress, headache, itching (urticaria), Stevens Johnson syndrome
☐	Section 2 - Epilepsy: Lamotrigine, Levetiracetam, Topiramate and Valproic Acid (23:27)
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☐	Section 3 - Epilepsy: Carbamazepine, Phenytoin, Gabapentin, Tiagabine, (28:51)
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☐	Section 4 - Barbiturates (10:31)
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☐	Section 5 - Benzodiazepines (15:05)
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☐	Section 6 - Nonbenzodiazepine Hypnotics (8:55)
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☐	Section 7 - Suvorexant (6:18)
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☐	Section 8 - Ramelteon (4:02)
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☐	Section 9 - Triptans (8:24)
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☐	Section 10 - Dopamine Agonists (9:00)
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☐	Section 11 - Carbidopa/Levodopa, COMT Inhibitors (Entacapone, Tolcapone) (14:07)
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☐	Section 12 - Dopamine Availability (Amantadine) (4:23)
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☐	Section 13 - Alzheimer Disease Treatment (Donepezil, Rivastigmine, Galantamine, Memantine) (6:10)
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☐	Section 14 - Riluzole (4:13)
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☐	Section 15 - Tetrabenazine (3:47)
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☐	Section 16 - Inhaled Anesthetics (8:46)
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☐	Section 17 - IV Anesthetics (13:39)
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☐	Section 18 - Local Anesthetics (16:35)
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☐	Section 19 - Neuromuscular Blocking Drugs (19:18)
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☐	Section 20 - Baclofen, Tizanidine, and Cyclobenzaprine (6:28)
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☐	Section 21 - Opioid Clinical Use, Mechanism and Overdose (18:58)
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☐	Section 22 - Mixed Agonist and Antagonist Opioids (Nalbuphine, Pentazocine, Butorphanol) (9:56)
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☐	Section 23 - Tramadol (5:22)
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☐	Section 24 - Glaucoma: Decrease Aqueous Humor Synthesis (13:59)
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☐	Section 25 - Glaucoma: Increase Outflow of Aqueous Humor (14:49)
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☐	Section 1 - Serotonin Syndrome (5:50)
TOPICS: Serotonin syndrome, 5-HT, caused by any drug that increases serotonin, clonus, hyperreflexia, hypertonia, tremors, seizures, autonomic instability, hyperthermia, diaphoresis, diarrhea, altered mental status, cyproheptadine, 5-HT2 receptor antagonist
☐	Section 2 - Neuroleptic Malignant Syndrome (9:38)
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☐	Section 3 - Extrapyramidal Symptoms (including Acute Dystonia) (11:49)
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☐	Section 4 - CNS Depressants Overview (8:12)
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☐	Section 5 - Alcohol (13:08)
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☐	Section 6 - CNS Stimulants Overview (8:00)
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☐	Section 7 - Amphetamines and Methylphenidate (12:05)
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☐	Section 8 - Caffeine (3:37)
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☐	Section 9 - Cocaine (14:20)
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☐	Section 10 - Nicotine (6:11)
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☐	Section 11 - LSD (2:29)
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☐	Section 12 - Marijuana (7:10)
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☐	Section 13 - MDMA (7:19)
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☐	Section 14 - PCP (4:40)
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☐	Section 15 - Typical Antipsychotic (13:57)
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☐	Section 16 - Atypical Antipsychotic (13:17)
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☐	Section 17 - Lithium (11:20)
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☐	Section 18 - Buspirone (4:40)
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☐	Section 19 - SSRIs (11:15)
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☐	Section 20 - SNRIs (9:21)
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☐	Section 21 - Tricyclic Antidepressants (12:41)
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☐	Section 22 - Monoamine Oxidase Inhibitors (12:13)
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☐	Section 23 - Bupropion (6:34)
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☐	Section 24 - Mirtazapine (7:13)
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☐	Section 25 - Trazodone (7:13)
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☐	Section 26 - Varenicline (4:50)
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☐	Section 27 - Vilazodone (6:18)
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☐	Section 28 - Vortioxetine (7:41)
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☐	Section 29 - Antidepressant Discontinuation Syndrome (3:37)
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☐	Section 30- Opioid Withdrawal, Detoxification and Relapse Prevention (15:19)
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☐	Section 1 - Mannitol (4:21)
TOPICS: Mannitol, osmotic diuretic, intracranial hypertension, intraocular pressure, pulmonary edema, high or low sodium, dehydration, contraindicated in renal failure, heart failure
☐	Section 2 - Acetazolamide (7:11)
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☐	Section 3 - Loop Diuretics and Ethacrynic Acid (12:28)
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☐	Section 4 - Thiazide Diuretics (8:01)
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☐	Section 5 - Potassium-sparing Diuretics (10:08)
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☐	Section 6 - ACE Inhibitors (9:21)
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☐	Section 7 - Angiotensin II Receptor Blockers (6:00)
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☐	Section 8 - Aliskiren (5:24)
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☐	Section 1 - Leuprolide, Goserelin and Degarelix (13:10)
TOPICS: Goserelin, leuprolide, gnrh analogs, pulsatile fashion they acts as gnrh agonists, continuous use they act as gnrh antagonists, decreased lh and fsh, low testosterone, leydig cells, decreased estrogen synthesis, granulosa cells, uterine fibroids, endometriosis, precocious puberty, prostatic carcinoma, infertility, hypogonadism, decrease libido, erectile dysfunction, nausea, vomiting, degarelix, gnrh antagonist, hot flashes, liver toxicity
☐	Section 2 - Estrogens and Hormone Replacement Therapy (11:49)
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☐	Section 3 - Raloxifene, Clomiphene, Tamoxifen (12:31)
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☐	Section 4 - Aromatase Inhibitors (5:17)
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☐	Section 5 - Progestins & Antiprogestins (13:53)
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☐	Section 6 - Combined Contraception and Copper IUDs (12:04)
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☐	Section 7 - Tocolytics (4:22)
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☐	Section 8 - Danazol (6:52)
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☐	Section 9- Testosterone, Methyltestosterone (7:32)
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☐	Section 10 - Antiandrogens (12:40)
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☐	Section 11 - Phosphodiesterase type 5 inhibitors (10:22)
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☐	Section 12 - Micturition Control (14:22)
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☐	Section 13 - Minoxidil (6:56)
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☐	Section 1 - Histamine-1 Blockers (9:51)
TOPICS: H-1 blockers, first generation H1 blockers, blood brain barrier, more side effects, diphenhydramine, chlorpheniramine, dimenhydrinate, doxylamine, treat allergies, motion sickness, sleep aid, sedation, antimuscarinic effects, anti alpha adrenergic effects, hypotension, tachycardia, second generation H1 blockers, loratadine, fexofenadine, desloratadine, cetirizine, treat allergies, less sedating
☐	Section 2 - Dextromethorphan and Guaifenesin (4:25)
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☐	Section 3 - N-acetylcysteine (1:56)
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☐	Section 4 - Pseudoephedrine, Phenylephrine (11:09)
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☐	Section 5 - Pulmonary HTN Drugs (10:04)
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☐	Section 6 - Asthma Treatment (10:36)
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☐	Section 7 - Alternative Asthma Treatment (12:10)
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☐	Section 8 - Anti-IL-5 Monoclonal Therapy (4:52)
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