Neuro Pharmacology Section 5- Benzodiazepines

TOPICS: Benzodiazepines, alprazolam, oxazepam, triazolam, midazolam, diazepam, lorazepam, temazepam, chlordiazepoxide, stimulate GABAa, increase frequency of chloride channel opening, detoxification, alcohol withdrawal, akathisia, feeling of restlessness, insomnia, anxiety, panic disorder, muscle spasticity, general anesthetic, amnestic effects, muscle relaxant effects, seizures, status epilepticus, cocaine intoxication, sleepwalking, night terrors, decreased delta wave (N3) sleep, decrease REM sleep, respiratory depression, contraindicated with alcohol, contraindicated with 1st generation antihistamines, dependence, sedation, liver disease, flumazenil competitive GABAa receptor antagonist, precipitate seizures, alcohol withdrawal, sleep disturbances

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