TOPICS: T cell differentiation and maturation, T cell activation, signal 1, signal 2, anergy, major histocompatibility complex (MHC) class I, major histocompatibility complex (MHC) class II, CD4, CD8, B7 protein (CD 80/86), dendritic cells, CD28, naive T cells, antigen-presenting cell (APC), CD28, T cell receptor (TCR), T cell sublets, cytokine stimulation, IPEX syndrome, FOXP3 mutation, autoimmunity, immune dysregulation, polyendocrinopathy, enteropathy, nail dystrophy, dermatitis, diabetes