TOPICS: LYST gene defect, microtubule dysfunction, autosomal recessive, defective lysosomal transportation, large granules, pyogenic infections, neutrophils, melanosomes, melanocytes, partial oculocutaneous albinism, defective granules in platelets, Schwann cells, progressive neurodegeneration, peripheral neuropathy, pancytopenia, hemophagocytic lymphohistiocytosis (HLH)