Hem/Onc Pharmacology Section 3- Warfarin

TOPICS: Warfarin, anticoagulant, hepatic epoxide reductase, vitamin k, gamma carboxylation factors, factor II, factor VII, factor IX, factor X, proteins c and s, half life, therapeutics index, pt, inr, cytochrome p450, vkorc1, ischemic stroke, pulmonary embolism, deep vein thrombosis, atrial fibrillation, hypercoagulation, skin necrosis, heparin, bleeding, hemorrhagic blisters, painful purpura, teratogenic, active bleeding, ulcer related gi bleeding, pericarditis, endocarditis, recent surgery, pregnancy, mechanical heart valve, vitamin k administration, fresh frozen plasma, prothrombin complex concentrate, cytochrome p450 inducers, gastric acid inhibition, cholestyramine, cytochrome p450 inducers, acetaminophen, sulfonamide, sulfonylurea, gut flora
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