General Pathology Section 6- Amyloidosis

TOPICS: Misfolded protein, extracellular space, β-pleated structure, systemic localized, congo red, Apple-green birefringence under polarized light, Systemic amyloidosis, multiple organs, Primary: AL (amyloid light chain) amyloid, Secondary: AA (amyloid-associated A protein) amyloid, immunoglobulin light chain, plasma cells, multiple myeloma, SAA (serum amyloid protein), acute phase reactant, chronic inflammation, infections, malignancy, asymptomatic proteinuria, nephrotic syndrome, restrictive cardiomyopathy, arrhythmia, heart block, waxy thickening, easy bruising, purpura, hepatomegaly, neuropathy, large tongue, malabsorption, Localized amyloidosis, single organ, Alzheimer disease, Age-related (senile) cardiac amyloidosis, Familial amyloid cardiomyopathy, Diabetes mellitus type II, Dialysis-related amyloidosis, Medullary carcinoma of the thyroid, Cerebral amyloid angiopathy, Aβ amyloid, β-APP (beta amyloid precursor protein), chromosome 21, normal transthyretin, mutated transthyretin proteinmutated TTR amyloid restrictive cardiomyopathyFamilial disease (African Americans), Amylin islets of the pancreas, β2-microglobulin, joints, calcitonin, amyloid stroma, β-amyloid, arteries in the brain, hemorrhagic stroke, subcutaneous abdominal fat, rectal mucosa, Congo red stain, Polarized light with apple-green birefringence, Treatment, Transplantation

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