General Pathology Section 5- Free Radical Injury

TOPICS: Free radicals, highly reactive chemical species, unpaired valence electrons, cellular injury, oxidative phosphorylation, electron transport chain, oxygen (O2), cytochrome c oxidase (complex IV), partial reduction of oxygen, superoxide (O2-), hydrogen peroxide (H2O2), hydroxyl radicals (•OH), radiation exposure, hydroxyl radicals, drugs and toxins, hepatic P450 enzymes, carbon tetrachloride, CCl3, cigarette smoke, smoking, inflammation, superoxide, NADPH oxidase, hypochlorite (OCl•), oxidative burst, free iron, Fenton reaction, copper, spontaneous decay, metal binding proteins, ceruloplasmin, transferrin, scavenging enzymes, glutathione peroxidase, catalase, superoxide dismutase, antioxidants, vitamins, glutathione, acetaminophen, acute liver failure, NAPQI, glutathione stores, hepatotoxicity, massive hepatic necrosis, oxygen toxicity, reperfusion injury, myocardial and cerebral ischemia, ischemic damage, O2-derived free radicals

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