TOPICS: Transketolase, branched chain alpha-ketoacid dehydrogenase, TCA cycle, alpha-ketoglutarate dehydrogenase, pyruvate dehydrogenase, glycolysis, pyruvate, acetyl CoA, thiamine deficiency, malnutrition, dry beriberi, wet beriberi muscle wasting, polyneuropathy, edema, dilated cardiomyopathy, alcoholism, Wernicke-Korsakoff syndrome, ataxia, ophthalmoplegia, mammillary bodies hemorrhage and necrosis